BioPQQ™, Pyrroloquinoline quinone (PQQ)

Figure: BioPQQ™ logo

Photo: Structural formula of Pyrroloquinoline quinone disodium salt

Pyrroloquinoline quinone was discovered as the third coenzyme for oxidoreductases next to nicotinamide adenine dinucleotide (NAD) and flavin adenine dinucleotide (FAD) in 1979. In 2003, Researchers of Riken reported the possibility that Pyrroloquinoline quinone is the 14th vitamin in mammals. Pyrroloquinoline quinone has potent anti-oxidative and nerve protective activities. We have established our original manufacturing technology of Pyrroloquinoline quinone by fermentation of bacteria, and put it on the market as food ingredient.

Pyrroloquinoline quinone has great potential as a safe ingredient of dietary supplement for the brain.


Physiological Activity

  • Anti-oxidative activity
  • Protection of neurons
  • Regeneration of neurons
  • Promotion of synthesis of nerve growth factor (NGF)
  • Improvement of memory and learning capacity
  • Activation of mitochondria


Examination item Value of standard Test method
Purity > 99.0% HPLC
Property Reddish brown powder Visual inspection
UV absorption 0.90±0.09 (A223/A259) Spectrophotometry
0.56±0.03 (A322/A259)
Water < 12.0% Karl Fisher method
Na/PQQ Min: 1.70
Max: 2.10
Heavy metal(as Pb, Cr, Cd) < 10ppm Atomic absorption method
Arsenic < 2ppm Atomic absorption method
General bacteria < 300cfu/g Examination of food hygiene guidance (JP)
Coliform bacteria Negative Examination of food hygiene guidance (JP)
Fungus Negative Examination of food hygiene guidance (JP)


Size Inner bag Outer package
500g aluminum bag corrugated cardboard case

Storage method

Seal and avoid moisture absorption, store at room temperature and in the dark

Expiration date

3 years from the date of manufacture

Inquiries Concerning Products

Green Energy & Chemicals Business Sector
Life Sciences Division  
TEL:+81-3-3283-4893 / FAX:+81-3-3214-0930