Quality and Safety

MGC is ISO9001, ISO14001, and GMP certified, and has been manufacturing coenzyme Q10 for over 25 years under Japanese GMP administration.
BioQ10, which is produced using MGC’s unique continuous culture technology, is a product of the highest quality with a purity of over 99%, easily surpassing JP, USP, and EP reference values.

With regards to the safety of taking coenzyme Q10 (CoQ10) in large doses, in American clinical trials in which Parkinson’s Disease patients were given doses of CoQ10 of 1,200mg per day for a period of 16 months, and in which ALS (amyotrophic lateral sclerosis) patients were given doses of 3,000mg per day for a period of 8 months, no side effects were observed. However, in Japan there have been virtually no case studies of large dose administration.
Therefore, MGC performed safety tests on healthy, Japanese adults to confirm the effects of large doses of CoQ10 on safety. The details of the safety tests are as follows.

• Group A (20 people): 900mg of MGC BioQ10 was administered daily for four consecutive weeks (300mg were administered 3 times a day).
• Group B (20 people): In place of BioQ10, a placebo was administered for the same period.

Before the tests, at two and four weeks during the tests, and after the tests, both groups underwent physical examinations, hematologic tests, biochemical blood tests, and urine tests in addition to having CoQ10 concentrations in the blood measured.
As a result, MGC confirmed that ingestion of large doses of BioQ10 caused no abnormal fluctuations in the clinical tests nor any harmful effects, and in addition no abnormalities were found in the test subjects’ medical examinations.
Also, MGC conducted further safety tests on rats by administering consecutive, repeated large doses for 52 weeks to test chronic toxicity, but no toxicity was discovered.